Klinisk Øjenforskningsenhed

Øjenafdelingen, Roskilde Universitetshospital


Roskilde, May 15th, 2015

Research at the Department of Ophthalmology, Copenhagen University Hospital Roskilde and the Faculty of Health Sciences, University of Copenhagen Denmark


Clinical Eye Research Unit currently consists of 2 senior researcher, 3 ph.d.-students, 2 research nurses and 1 opticians, and is headed by Clinical professor Torben Lykke Sørensen, MD DMSc.


Research focus

Our research covers both immunological studies of age-related macular degeneration, but also more clinical studies involving questionnaires, symptoms such as the Charles Bonnet Syndrome, evaluation of treatment results, and other aspects of disease pathogenesis (inflammation, exercise, depression). We also study the effect of gastric bypass surgery and the development of diabetic retinopathy. Another focus is research in pre-school refraction abnormalities and screening.


We participate in international multi-centre randomized clinical trials.


Other than the above mentioned projects, smaller studies dealing with different diseases and imaging techniques are currently ongoing.



Dept. of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet
Institute of Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen
Dept. of Neurology, Copenhagen University Hospital Rigshospitalet
Dept. of Odontology, Faculty of Health Sciences, University of Copenhagen
Dept. of Opthhalmology, Aalborg University Hospital
Institute for Cellular and Molecular Medicine, University of Copenhagen
Dept. of Ophthalmology, Copenhagen University Hospital Glostrup
Kyoto Eye and Vision Research Center, Kyoto, Japan



Grants and support

Our research has been supported by Velux Foundation, Fight for Sight Denmark, Synoptik Foundation, Ejner Villumsens Foundation, Beckett-Fonden and Protection for Sight Foundation Denmark.


Completed PHDs

Amardeep Singh. Systemic changes in neovascular AMD. 2014
Mads Falk. Chemokines in age-related macular degeneration. 2014



Current staff

Chief physician, Clinical Associate Research Professor

Torben Lykke Sørensen, MD DMSc

tlso@regionsjaelland.dk / torbenls@dadlnet.dk


Chief physician, Associate Professor

Inger Christine Munch, MD PhD



Chief physician, Associate Professor

Lisbeth Jelveh Sandfeld, MD PhD



Clinical Post-doc, part-time

Amardeep Singh, MD




Clinical PhD Fellow

Troels Brynskov, MD



Clinical PhD Fellow

Marie Krogh Nielsen, MD




Clinical PhD Fellow

Yousif Subhi, MD




Research Nurse

Gitte Ø. Henningsen, RN




Research Nurse

Charlotte T. Larsen, RN




Sophie Madsen

Optician and project coordinator





Text-book in Ophthalmology. 2015



Scholarly publications

TL Sørensen & Mortzos PM. Iritis, ptosis, and sequental severe visual loss in essential thrombocytosis. Eye 2009;24(5):928.


TL Sørensen, Mortzos PM, Øgard C. Social impairment and severe photophobia in phlyctenulas keratitis. Acta Pediatrica 2009;98(11); 1707-8.


TL Sørensen & Kemp H. Intravitreal Ranibizumab for aldersrelateret makuladegeneration. Ugeskrift for Læger 2010;172(22):1685-1689.


Øgard C, Kjærbo H, TL Sørensen. Sammenlimning af begge øjne skal ikke behandles konservativt. Ugeskrift for Læger 2010; 172(41):2846-2847.


A Singh & TL Sørensen. The prevalence and clinical characteristics of the Charles Bonnet Syndrome in a Danish patients with age-related macular degeneration. Acta Ophthalmol 2010; Nov 25 e-pub ahead of print.


TL Sørensen & Kemp H. Effect of Ranibizumab in patients with choroidal neovascularisation and very low vision. Acta Ophthalmol 2011; Feb 89(1):e97.


A Singh & TL Sørensen. Charles Bonney syndrome improves when treatment is effective in age-related macular degeneration. Br J Ophthalmol 2011; Feb(2):291- 2.


A Singh & TL Sørensen. Charles Bonnet Syndromet: Vigtig differentialdiagnose ved synshallucinationer. Ugeskrift for Læger 2011; 173:47-49.


A Singh & TL Sørensen. Angst ved Charles Bonnet Syndromet. Ugeskrift for Læger 2011:173:50.


MS Sørensen, S Andersen, GØ Henningsen, CT Larsen, TL Sørensen. Danish translation of Visual Function Questionnaire-25 and its use in age-related macular degeneration. Dan Med Bul 2011:58(6):A4290


A Singh & TL Sørensen. Incidence and regression of Charles Bonnet Syndrome in vascular age-related macular degeneration. Reply to Carsten H. Meyer et al. Br J Ophthalmol 2011: May:e-pub.


MS Eghøj & TL Sørensen. Tachyphylaxis development during treatment of exudative agerelated macular degeneration with ranibizumab. Br J Ophthalmol 2011 doi:10.1136.


Hamoudi H, Sørensen TL. Effect of intravitreal ranibizumab in the treatment of peripapillary choroidal neovascularisation. J Ophthalmol. 2011;2011:602729. Epub 2011 Dec 22.


Jørgensen JS, Kemp H, Sørensen TL. Identification of foreign bodies on the ocular surface after uneventful intravitreal injections. Acta Ophthalmol. 2012 Apr 4. 


Singh A, Faber C, Falk M, Nissen MH, Hviid TV, Sørensen TL. Altered Expression of CD46 and CD59 on Leukocytes in Neovascular Age-Related Macular Degeneration. Am J Ophthalmol. 2012 Jul;154(1):193-199.


M Falk, H Kemp, TL Sørensen. Four year follow-up on treatment of neovascular AMD and causes of discontinuation of treatment. Am J Ophthalmology 2012; Sep 27. pii: S0002-9394(12)00507-7.


J Halborg, TL Sørensen. Loss of retinal function and pigment epithelium changes in a patient with common variable immunodeficiency. Case Rep Ophthalmol Med. 2012;2012:967561. doi: 10.1155/2012/967561. Epub 2012 Sep 29.


A Singh, MK Falk, TVF Hviid, TL Sørensen. Increased Expression of CD200 on Circulating CD11b+Monocytes in Patients with Neovascular Age-Related Macular Degeneration. Ophthalmology 2013


T Brynskov, C Laugesen, TL Sørensen. Intravitreal ranibizumab for diabetic macular edema; one-year experiences in a clinical setting. Acta Ophthalmol 2013.


P Mortzos & TL Sørensen. Visual loss, homonymous hemianopsia and unilateral optic neuropathy as the presenting symptom of vertebrobasilar dolichoectasia. Case Reports in Ophthalmological Medicine 2013 .


T Brynskov, C Laugesen, J Halborg, H Kemp, TL Sørensen. Longstanding refractory pseudophakic cystoid macular edema resolved using intravitreal 0.7 mg dexamethasone implants. Clin Ophthalmol 2013.


I Rafique & IC Munch. New oportunities for the treatment of age related macular degeneration. Ugeskrift for Læger 2013; June 10


A Singh, M Falk, Y Subhi, TL Sørensen. The association between 25-hydroxyvitamin D and subgroups in age related Macular degeneration. A cross sectional study. PLOS One 2013.


T Brynskov, H Kemp, TL Sørensen. No cases of endophthalmitis after 20,293 intravitreal injections in an operating room setting. Retina 2013


Y Subhi, A Singh, M Falk, TL Sørensen. In patients with neovascular AMD physical activity may influence c-reactive protein levels. Clin Ophthalmol 2013


Y Leoson, C Øgard, P Mortzos. Conjunctival autograft as treatment for anterior displacement and scarring of the plica semilunaris after strabismus surgery. Journal of AAPOS 2013; 17: 528-529.


IC Munch, A Linneberg, M Larsen. Precursors of age-related macular degeneration: associations with physical activity, obesity, and serum lipids in the inter99 eye study. Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3932-40. doi: 10.1167/iovs.12-10785. PubMed PMID: 23652489.


A Singh, Y Subhi, TL Sørensen. Low awarness of the Charles Bonnet Syndrome in patients attending a retina clinic. Dan Med J 2013.


T Brynskov, H Kemp, TL Sørensen. Intravitreal ranibizumab for retinal vein occlusion through 1 year use in clinical practice. Retina 2013.


Y Subhi, G Henningsen, CT Larsen, MS Sørensen, TL Sørensen. Foveal morphology affects self-percieved visual function and treatment response in age-related macular degeneration. A cohort study. Plos One 2014.


M Falk, A Singh, C Faber, MH Nissen, TH Hviid, TL Sørensen. Blood expression levels of chemokine receptor CCR3 and chemokine CCL11 in age-related macular degeneration. A case-control study. BMC Ophthalmology 2014.


M Falk, A Singh, C Faber, MH Nissen, TH Hviid, TL Sørensen. Dysregulation of CXCR3 in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 2014.


A Singh, P Mortzos, TL Sørensen. Visual hallucinations in patient suffering from carotic artery dissection. Case Reports in Ophthalmology. 2014

P Mortzos, MM Nordling, TL Sørensen. Eight and a half syndrome as the presenting sign of pediatric multiple sclerosis. JAPPOS 2014


Falk MK, Singh A, Faber C, Nissen MH, Hviid T, Sørensen TL. CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. PLoS One. 2014 Dec 15;9(12):e112473.



Publications on work conducted with participation by our department

SL von Holstein, J Østergaard, S Daugaard, PB Toft, S Heegaard. Granular cell tumour of the lacrimal gland. Acta Ophthalmol 2009 doi:10.1111


KL Rasmussen, CS Laugesen, L Ringholm, M Vestgaard, P Damm, ER Mathiesen. Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes. Diabetologia 2010;53:1076-1083.


L Ringholm, M Vestgaard, CS Laugesen, A Juul, P Damm, ER Mathiesen. Pregnancyinduced increase in circulating IGF-1 is associated with progression of diabetic retinopathy in women with type 1 diabetes. Growth Hormone & IGF Research 2011;21:25-30.


CD Lynggaard, P Theil, G Jemec. Childhood rosacea: A review and case report. Forum for Nord Derm Ven 2009;14(3):68-70.


J Østergaard, JU Prause, S Heegaard. Oncocytic lesions of the ophthalmic region: a clinicopahtological study with emphasis on cytokeratin expression. Acta Ophthalmol 2011;89(3):263-267


A Storr-Paulsen, A Singh, H Jeppesen, JC Norregaard, J Thulesen. Corneal endothelial morphology and central thickness in patients with type II diabetes mellitus. Acta Ophthalmol 2013 Feb 7. doi: 10.1111/aos.12064


C Faber, A SinghM Kruger Falk, HB Juul, TL Sørensen, MH Nissen. Age-related macular degeneration is associated with increased proportion of CD56+ T cells. Ophthalmology 2013 (in press). 


GL Hansen, PK Kofoed, Munch IC, Sillesen H, Jensen LP, Iversen HK, Larsen M. Retinal angiographic blood flowmetry is reduced in the ocular ischaemic syndrome. Dan Med J. 2013 Oct;60(10):A4716. PubMed PMID: 24083530.


Nagiel A, Freund KB, Spaide RF, Munch IC, Larsen M, Sarraf D. Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Nov;156(5):981-988.e2. doi: 10.1016/j.ajo.2013.06.024. Epub 2013 Aug 20. PubMed PMID: 23972309.


Willerslev A, Li XQ, Munch IC, Larsen M. Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations. Acta Ophthalmol. 2013 Jul 2. doi: 10.1111/aos.12233. [Epub ahead of print] PubMed PMID: 23819809.


Willerslev A, Li XQ, Cordtz P, Munch IC, Larsen M. Retinal and choroidal intravascular spectral-domain optical coherence tomography. Acta Ophthalmol. 2013 Apr 1. doi: 10.1111/aos.12048. [Epub ahead of print] PubMed PMID: 23552098.


M Bagger, JF Tebering, JF Kiilgaard. The ocular consequences and applicability of minimally invasive 25-gauge transvitreal retinochoroidal biopsy. Ophthalmology 2013;1-8

Scott I, Jackson G, Quillen D, Larsen M, Klein R, Liao J, Holfort S, Munch I, Gardner T. Effect of Doxycycline vs Placebo on Retinal Function and Diabetic Retinopathy Progression in Patients With Severe Nonproliferative or Non-High-Risk Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA Ophthalmology 2014: e-pub.


Modvig S, Degn M, Roed H, Sørensen T, Larsson H, Langkilde A, Frederiksen J, Sellebjerg F. Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis. Mult Scler. 2015 Feb 19.




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